rosenberg film 9

Cancer kills more than six hundred thousand people every year.

Though there have been great strides made in the fight against cancer, we are still losing the battle each year.

Cancer Affects All Kinds of People at All Ages

Even for public figures, celebrities and those who we would consider wealthy, there is no protection from the disease that confounds most experts.

Taking people like Peter Jennings, Farrah Faucet, David Bowie, Aretha Franklin, Paul Newman, Walt Disney, Dennis Hopper and countless more, in the midst of their prime, cancer does not choose only the elderly.

So many people have already died, from a disease that knows no age differences, from ten year olds, to thirty-somethings in their prime, to seniors, who were lucky enough to live a full life, before this terrible disease struck them down.

Cancer Trends

Although statistical trends are usually not directly applicable to individual patients, they are essential for governments, policy makers, health professionals, and researchers.

These statistics and trends enable us to understand the impact of cancer on the population, and to develop strategies to address the challenges that cancer poses to the society at large.

Many Patients Dying Of Cancer Try Useless Treatments

WebMD reports new research indicates that when given just one month to live, a significant number of patients still opt for aggressive and often costly interventions, despite little evidence to suggest they’ll help.

A study of just over 100,000 patients in the United States found that the urge to undergo ultimately fruitless cancer treatment “is not a rare phenomenon,” said study author Dr. Helmneh Sineshaw, of the American Cancer Society.

More than one-quarter underwent active treatment, such as surgery or chemotherapy, in the final weeks of life, said Sineshaw, director of treatment patterns and outcomes research for the cancer society.

For those affected, care planning can be very “complex.” Decisions involve a tricky interplay of doctors, patients and loved ones.

Though this is a challenging scenario for doctors and patients, oncologists have an obligation to inform their patients as best as they can about the prognosis, the goals of treatment, and the expectations for benefit and side effects from any treatment plan.

However, there is hope, from doctors like Dr. Mark Rosenberg, from the Healthy Living Group.

Dr. Rosenberg is an innovator with original ideas on how to combat this disease.

It is because of rare individuals like Dr. Rosenberg that progress is finally being made, and the long struggle against cancer may ultimately be won.

Why People Seek Out Dr. Rosenberg’s Methods

Cancer is a very personal disease. What we know about cancer and how to fight it and provide the best options for our patients is continually being supplemented or challenged by new and exciting studies.

Marina’s Story

Marina Ashville had complained of an odd type of lump stretch mark for years on her right breast, but was told by doctors not to worry because it was nothing. Finally she went for a sonogram with the urging of her daughter Anna. They were shocked to find out that Marina had stage 2 estrogen positive breast cancer.

In 2018, she began experiencing bone pain, which became persistent. A PET scan showed a large spread of disease in her bones. After new scans and tests, they would find Marina now had stage 4 cancer which spread to her bones. With the news, Anna her daughter, took six months off of work to step in and roll up her sleeves to be her mom’s advocate.

Anna decided to look outside the traditional box of standard care, in hopes of finding a new cutting edge direction that could offer her mother a better chance at life.

This journey would bring her to the offices of Dr. Mark Rosenberg, an integrative medicine doctor, who specializes in care for various stages of cancer patients.

So far, following the trail blazing approach of Dr. Rosenberg, Marina is thriving with his treatment regiments, and her pain has vanished.

In 2019, Emmy-award winner Director and Producer Keith Famie will dedicate his next film to the ravages of cancer, giving a voice to those who are in the midst of a terrifying journey.

He will explore the latest medical advances as well as body, mind and spirit approaches and cures that may come from natural sources. An in-depth look will be taken as to how lifestyle changes and discipline can affect what may otherwise be a genetic roll of the dice.

As with all of Keith’s documentaries, the production will contrast real-time stories of cancer patients with those on the front-line of researching cures. The newest approaches will be examined, including advancements being made in chemotherapy and holistic medicine.

As an Emergency Room physician, Dr. Mark Rosenberg saw all kinds of patients, but when his mother came in complaining of pain it was a shock when he diagnosed her with stage four metastatic cancer after reviewing the scans of her lungs.

That was 16 years ago. Since that moment, Dr. Mark felt lost at this time in not being able to help his mother.

So he decided to dedicate the rest of his career to treating cancer patients through an integrative medical approach.

How Dr. Rosenberg Helps His Patients Stay Alive

Mark A. Rosenberg, MD is President and Medical Director of Advanced Medical Therapeuetics and Integrative Cancer Therapeutics in Boca Raton, Florida.

He is also Program Director of Integrative Cancer Fellowship, Chief Medical Officer of Laboratory for Advanced Medicine, as well as Co-founder of Channel Therapeutics  LLC and Co-founder of High Point Therapeutics LLC. With the Adaptive Cancer Care Essentials Program (ACCEP) which Dr. Mark Rosenberg created to serve the medical community, he uses his discoveries with Immunotherapy, low dose metronomic chemotherapy, off-label use of medicines, IV Vitamin C, hyperthermia, nutraceuticals, and more, to bring relief to his grateful patients.

Dr. Rosenberg is leading the cutting edge helping his patients live with their cancer in an ongoing manner.

Dr. Rosenberg’s ongoing advances have changed the way both doctors and patients think about addressing and living with cancer.

Whether you are a doctor in the fight against cancer, a cancer patient, or a family member fighting the fight right alongside your loved one…

It pays to get the all the details Dr. Rosenberg has uncovered…

To help cancer patients live with their cancer.

Discover more about the ACCEP Program Today.

October 21st, 2019

Posted In: Cancer Prevention

Leave a Comment

proton pump

Repositioning of proton pump inhibitors in cancer therapy — download the full PPI from Cancer Chemother Pharmacol by Zhen-Ning Lui, Bing Tian, and Xiu-Li Guo.

 

Many of you may be aware that I have concentrated my cancer research on the glycolytic nature of many cancers. Cancers that are glycolytic, such as GBM and triple negative breast cancer, primarily rely on glycolysis for the generation of ATP, rather than mitochondrial ox-phos. The end product of glycolysis is pyruvate, which then will be converted into lactic acid. These glycolytic cancer cells must upregulate their mechanism(s) for effluxing lactic acid, or else they will succumb to necrosis or apoptosis, secondary to acidosis.

Any one or combination of 6 mechanisms may be upregulated, but commonly, the proton pump is one of the mechanisms upregulated.

A study was performed in 2012, in which adult females with metastatic breast cancer were randomly assigned to 3 arms: Arm A; Docetaxol 75 mg/m2 and cisplatin 75 mg/m2 on day 4, repeat q 21 days; Arm B; The same chemotherapy plus oral esomeprazole 80 mg bid on days 1-3, Arm C; The same as Arm B except esomeprazole 100 mg bid. Median progression free survival: Arm A (N = 33) 7.5 months; Arm B (N = 30) 10.9 months; Arm C (N= 31) 9.5 months. Among 17 patients with triple negative breast cancer this difference was bigger with median PFS of 9.5 and 3.3 months respectively.

The reason that the great difference was seen in the triple negative group, was that triple negative breast cancer is typically the most glycolytic of the breast cancers. Although the data indicates that long term use of proton pump inhibitors in the healthy population may lead to nutritional deficiencies, as well as altering the bacterial flora, the data suggests using PPIs may be a helpful adjunct in patients with advanced-stage glycolytic cancers.

August 27th, 2019

Posted In: cancer care, Cancer Prevention

Tags: , , , , ,

Leave a Comment

retinoic acid
Retinoic acid may improve immune response against melanoma — an article from Science Daily.

Myeloid derived suppressor cells (MDSC) play an important role in tumor progression. In cancer patients, the presence of MDSCs is associated with low survival rates and tumor recurrence.

MDSCs have a remarkable ability to suppress T-cell responses and to modulate the fate of multiple cells of the innate immune system. MDSCs utilize multiple mechanisms targeting the effector functions of cells involved in both the innate and adaptive immune responses to suppress anti-tumor immunity.

As stated in the article, retinoic acid stimulates MDSC to differentiate into immune-supporting cells. In addition, All-trans-retinoic acid (ATRA) is a potent differentiating agent, stimulating cancer stem cells to differentiate into less aggressive/resistant cells.

In the new study that has just started enrollment, All-trans retinoic acid (brand name – Vesanoid), is being used at a dose of 150 mg/m2 orally for 3 days surrounding each of the first four infusions of pembrolizumab. There are multiple studies that are ongoing, evaluating the combination of ATRA with chemotherapy and immunotherapy, ranging from doses of 20 mg/m2 up to 150 mg/m2.

ATRA is not specific to the treatment of melanoma; it may be used as an adjunct when treating any cancer.

 

August 15th, 2019

Posted In: cancer care

Tags: , , , , , , , , , , , ,

Leave a Comment

Prostate cancer ultrasound treatment as effective as surgery or radiotherapy – an article by Imperial College London.
This is a ground-breaking and game-changing study for males. For may years, the only curative treatment for males with prostate cancer that had not spread outside the prostate was surgery or radiation therapy.

What is particularly exciting about this study, is that many of these patients were “high-risk,” meaning they could have a PSA of at least 20, a Gleason Score of 8-10, and or presumed extraprostatic extension on digital rectal examination.
Now we have data indicating that a large percentage of patients diagnosed with prostate cancer can have treatment equal to the efficacy of surgery or radiation, with a significantly reduced incidence of urinary incontinence and/or erectile dysfunction. Keep in mind, however, that it has only recently been FDA-approved in the U.S., so success can be operator dependent.

 

July 23rd, 2019

Posted In: cancer care

Tags: , , , , , , ,

Leave a Comment

low dose chemo
Low-dose Chemotherapy Protocol Relies on Normalization of Tumor Blood Supply – an article from Massachusetts General Hospital.
If you search metronomic chemotherapy at clinicaltrials.gov, you will find at least 178 citations. While most oncologists will tell you that either low dose chemotherapy does not work, or that there has not been a randomized trial comparing standard of care to low dose metronomic, this concept is attracting plenty of attention from the academicians.
While cytotoxic chemotherapy works only through direct killing of cancer cells (and normal cells), low dose metronomic chemotherapy targets tumor vasculature, improves the host anti-cancer immune response, improves blood supply to the tumor (thereby increasing chemotherapy delivery to the tumor, as well as oxygen delivery, which then turns off HIF-1 alpha), and improves the tumor stroma to favor a host anti-tumor response.
Unfortunately, one size never fits all, so even low dose metronomic chemotherapy needs to be altered (dose and frequency) according to tumor response. The data continues to mount, and in the near-future, maximum tolerated dose chemotherapy, in the treatment of solid tumors, will no longer be the norm.

 

July 8th, 2019

Posted In: cancer care

Tags: , , , , ,

Leave a Comment

Doctor greating patient

Testosterone Research Brings New Hope for Cancer Patients – an article from Science Daily.

This is certainly not the first article published on the benefits of anabolic steroids for cancer cachexia. Anabolic steroids, such as testosterone and nandrolone, not only reduce muscle wasting, they also increase erythropoietin release, thereby mitigating the anemia and fatigue associated with maximum tolerated dose regimens. This affords the patients less transfusions, as well as a decreased need for erythropoietin stimulating agents, which have shown to increase mortality in cancer patients.

Commonly recommended drugs for appetite stimulation, such as progestins, corticosteroids, and dronabinol, are minimally and transiently effective. In addition, there is no risk of promoting the aggressiveness of the cancer with anabolic steroids if the cancer does not possess androgen receptors. To the contrary, breast cancer survivors who received subcutaneous implants containing testosterone in combination with a low dose of anastrozole for relief of menopausal symptoms, have had no recurrence of cancer after eight years of testosterone therapy.
Bottom line: consider the use of anabolic steroids for cancer cachexia, as long as the cancer does not possess androgen receptors, such as prostate cancer and often triple negative breast cancer.

June 20th, 2019

Posted In: cancer care

Tags: , , , , ,

Leave a Comment

breast cancer

New Research Finds That Routine Breast Cancer Tests Lead to Unnecessary Mastectomies and Chemotherapy – an article from Cancer News.

This article may temper the celebrity-endorsed enthusiasm for prophylactic mastectomies for those with BRCA mutations. In addition, another study out of Duke Cancer Institute followed women with a BRCA mutation who had been diagnosed with ovarian cancer, with one group having prophylactic mastectomies, and the other group receiving routine screening (mammograms/MRIs); you can read the article here.

Results: For women diagnosed at any age with BRCA 1 and 2 gene mutations and within the first four years after ovarian cancer diagnosis, prophylactic mastectomy was associated with a negligible gain in survival. For women diagnosed at age 60 or older, regardless of time since ovarian cancer diagnosis, the gain in survival months was also negligible. For women diagnosed at age 40 to 50 with BRCA 1 and 2 mutations and at least five years after an ovarian cancer diagnosis, the procedure was associated with a survival benefit of two to five months.

Bottom line: Although prophylactic mastectomy in BRCA gene mutation carriers has shown to decrease breast cancer incidence, the data does not confirm an increase in survival.

 

June 11th, 2019

Posted In: cancer care, Cancer Prevention

Tags: , , , , , ,

Leave a Comment

Colorectal Cancer
This is not the first article to document the potential efficacy of the antifungal agent, itraconazole. Multiple studies have shown that itraconazole inhibits cancer, not only through WNT inhibition, but also, through reversing MDR (multidrug resistance gene), inhibiting the Hedgehog pathway, and inhibiting angiogenesis. Human data have been published using itraconazole with prostate cancer, NSC lung cancer, triple neg breast cancer, ovarian cancer, as well as other cancers.
I refer physicians to the following article, “Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent.” There are many drugs that have other FDA-approved indications that can and should be repurposed for use in cancer. I have personally used itraconazole in a patient with stage III NSC lung cancer who refused chemotherapy; he remained without progression of disease for 1.5 years, until he died of a drug overdose.

 

May 28th, 2019

Posted In: cancer care

Tags: , , , , , , , , , ,

Leave a Comment

Needle and Arm
Can Oncolytic Viruses Improve Immunotherapies? — an article from Cancer Therapy Advisor.

Most of the exciting current research in treating cancer revolves around immunotherapy. Although the PD-1, CTLA-4, and PD-L1 inhibitors have made a large impact in a subset of patients, the reality is that only approximately 20% of patients benefit from these checkpoint inhibitors.

Oncolytic viruses (OV) are interesting but, as a single agent, had not been successful because macrophages recognize infected cells and kill them together with their viruses. OV therapy, as a single agent, had not been successful because macrophages recognize infected cells and kill them together with their viruses.

Recent studies use new designs of OV that can stimulate cytotoxic T cells to kill cancer cells before the viral population is significantly depleted by the macrophages. Some of these studies introduce enhancement of the T cells by blocking their checkpoints. Mice experiments demonstrated that both CTLA-4 and PD-L1 checkpoints blockade enhance the OV treatment.

Although patients typically will enter a clinical trial to get a combination of oncolytic virus with checkpoint inhibitors, we have the ability to compassionately use these on patients, outside of a clinical trial.

Rigvir is a genetically unaltered oncolytic virus with approval in a few European countries. The efficacy data is extremely scarce and only for melanoma, but perhaps combined with checkpoint inhibition, its efficacy would improve. For those of you interested in treating patients with this combination, I will make myself available.

 

May 14th, 2019

Posted In: cancer care, Cancer Prevention

Tags: , , , , , ,

Leave a Comment

personalized vaccine

Personalized cancer vaccine may increase long-term survival in patients with deadly brain cancer — an article from Science Daily.

Unfortunately, with all of our new cancer drugs, we have been unable to improve survival for patients with glioblastoma (GBM). Northwest Biotherapeutics, Inc uses a personalized vaccine, by taking the patients’ tumor, and making a lysate from it. The brain tumor tissue lysate is then combined with the patients’ own dendritic cells, so the dendritic cells can “learn” what it needs to attack. These matured cells are then injected back into the patient.

Using this technique, we are seeing improved survival for GBM, certainly compared to any other modalities. When we sit back and attempt to discern the “big picture” in treating cancer, we keep coming back to the same concept: each patient with cancer must be treated uniquely and individually, because each cancer is a unique disease to each individual. In the future, if a patient presents to you with GBM, consider sending them for a clinical trial with Northwest Biotherapeutics, Inc.

April 23rd, 2019

Posted In: cancer care

Tags: , , , , ,

Leave a Comment

Next Page »